Saksham Kulkarni's acting career commenced as a child actor in the film Pak Pak Pakak, where he played the character of Chiklu/Chikhlu. This breakthrough role earned him the Best Male Actor award at the AsianFest in Singapore for a Marathi film.
As a child actor, Saksham appeared in a few movies, and later, he pursued his education, completing his Master's degree in Commerce. He then transitioned to adult acting, making his debut in the movie Kaksparsh.
In 2012, Saksham made his television debut with the comedy show Ambat God, starring alongside senior co-actors Sanjay Mone, Vishaka Subedar, Suhas Paranjape, and Vandana Gupte. He later appeared in a Hindi TV film, Life Main Hungama Hai, alongside Urmila Matondkar, and participated in the dance show Eka Peksha Ek Jodicha Mamla, alongside Gauri Vaidya.
Additionally, Saksham starred in the Hindi movie Allah Ke Bande, alongside Sharman Joshi.