Michael Wayne, the eldest son of John Wayne and his first wife Josephine Alicia Saenz, was born into a socially prominent Latina family residing in Los Angeles. He graduated from Loyola University of California in 1956 and later served in the U.S. Air Force Reserve. His fascination with film production began during the filming of John Ford's 1951 classic, The Quiet Man, where he worked as a production assistant alongside his father.
Michael Wayne joined his father's film production company, Batjac, during the production of The Alamo in 1960 and went on to become the line producer for McLintock! in 1963. He subsequently produced numerous star vehicles for his father, including Brannigan in 1975, The Green Berets in 1968, Big Jake in 1971, and The Train Robbers in 1973.
Following his father's passing from cancer in 1979, Michael Wayne assumed the role of head of Wayne Enterprises, which owns a significant portion of his father's film library. He also ventured into other business ventures, such as movie distribution, merchandising his father's image, real estate investments, and other entrepreneurial pursuits.
In addition to his business endeavors, Michael Wayne served as the chairman of the board of the John Wayne Cancer Institute at Saint John's Health Center, a testament to his commitment to his father's legacy and the fight against cancer.