Jacqueline Samantha Titone, a renowned model and actress, was born in 1974 in Coral Springs, Florida, to Lila Titone and Joseph Titone. Her modeling career began during high school, eventually gaining national and international recognition for representing prominent fashion brands.
Her entry into the acting world was facilitated by Rob Schneider, who introduced her to the film industry in the 1999 hit movie Deuce Bigalow: Male Gigolo, where she played the role of Sally. This initial success led to her being recommended to Adam Sandler, who offered her a part in the 1999 film Big Daddy, in which she played a waitress and music assistant.
In 2000, Jackie appeared in the movie Little Nicky, alongside Adam Sandler, Reese Witherspoon, Patricia Arquette, and Quentin Tarantino. Her relationship with Adam Sandler began the following year. Two years later, she was cast in the animated film Eight Crazy Nights (2002),voicing the character Jennifer, marking her first significant role alongside a prominent star.
In 2003, Danny DeVito offered Jackie a part in the movie Duplex, in which she played a bartender. On June 22, 2003, Jackie married Adam Sandler. In the 2004 hit comedy-romance film 50 First Dates, Adam Sandler and Drew Barrymore starred together, with Jackie being cast as the dentist due to Adam's insistence.
In 2004, Jackie appeared as herself in the TV episode Celebrity Weddings, just one day before her one-year wedding anniversary with Adam. Raised a Christian, she converted to Judaism upon marrying Adam.