Marisa Román's acting career began at the tender age of 15 when she started working with independent producer Laura Visconti Producciones, where she was cast in two juvenile series, "Así es la vida" and "La calle de los sueños." In 2001, she joined Venezuelan network RCTV, participating in the telenovelas "Viva la pepa," "A calzón quitao," and the leading role in the juvenile love plot of telenovela "Trapos íntimos," marking her last work for that network.
For the next decade, Marisa worked at Venevisión, the most important TV network in Venezuela. Her first project there was a dual role that made her a household name: the twins "Verónica" and "María Suspiro" in the popular and acclaimed telenovela "Cosita Rica" (2003-2004),which resulted in a host of awards and recognitions. In 2006, she landed the leading role in "Ciudad Bendita," another telenovela that garnered the highest ratings in Venezuela in the last decade.
Marisa's work in Venevisión continued with "La Vida Entera" (2008-2009),"La Mujer Perfecta" (2010 - 2011),and more recently, she led the cast of the telenovela "De Todas maneras Rosa" (2013). Her film career has also been consistent, with roles in "Elipsis," "Lo que tiene el otro," "Ni tan largos... ni tan cortos" (Award for best actress at the National Film Festival of Merida 2007),"Día Naranja," "La Hora Cero" (The Zero Hour) (Award for best actress in a supporting role at the National Film Festival of Merida 2010 and Award of the Public for all the crew at the LALIFF - Latino Film Festival of Los Angeles 2011),"Samuel," "Cuidado con lo que sueñas," "Memorias de un Soldado," and "Bloodbath Test."
On stage, Marisa has worked with the Grupo Actoral 80 in plays written by two of the best Venezuelan theater authors, Fausto Verdial's "¡Y... las mujeres también!" and "Los hombros de América," and José Ignacio Cabrujas' "El día que me quieras." Additionally, she has been the face and voice of Movistar, one of the largest mobile phone and Internet providers in Venezuela, and is also the spokeswoman of NGO Acción Solidaria, with whom she made a major public service campaign to raise awareness about HIV prevention and testing among young audiences.