Claudio Santamaria was born in Rome, Italy. He began his acting career on the big screen in 1998, but it wasn't until 2001 that he gained recognition with the film "L'Ultimo Bacio" directed by Gabriele Muccino.
Throughout his career, Santamaria has appeared in numerous films and television shows, including "Il Cartaio" by Dario Argento, "Torneranno I Prati" by Ermanno Olmi, "Casino Royale" by Martin Campbell, "600 Kilos d'or pur" by Eric Besnard, and "Pauline Dètective" by Marc Fitoussi.
He has also lent his voice to several characters, including Christian Bale's Batman in the Italian dubs of "Batman Begins", "The Dark Knight", and "The Dark Knight Rises", as well as Batman in "The Lego Movie", "LEGO Batman - The Movie", and "The LEGO Movie 2 - The Second Part". He also voiced Batman in the Spotify Podcast "Batman - Un'autopsia".
Santamaria has also made a name for himself in television, starring in the biopic "Rino Gaetano - Il Cielo è Sempre Più Blu" and performing all the songs in the series. He also appeared as the protagonist, Orlando Mieli, in the TV series "È Arrivata la Felicità", a romantic comedy that was acclaimed by the Italian public.
In recent years, Santamaria has worked in theatre, acting in "Occidente Solitario" by Martin McDonagh directed by Juan Diego Puerta Lopez and "Gospodin" by Philipp Lohle directed by Giorgio Barberio Corsetti.
In 2017, he won the David Di Donatello as Best Actor for his role as Enzo Ceccotti in "Lo Chiamavano Jeeg Robot" directed by Gabriele Mainetti. He has also directed several short films, including "The Millionairs" and "Brutti e Cattivi", and has worked with directors such as Gabriele Muccino, Antonio Morabito, and Gabriele Salvatores.
In 2020, he acted in the film "Gli Anni Più Belli" directed by Gabriele Muccino, and in 2021, he was presented in the 78th Venice International Film Festival with the film "Freaks Out" directed by Gabriele Mainetti. In 2022, he acted in the Sky series "Christian" directed by Stefano Lodovichi and Antonio Nicastro, and voiced the brave monster hunter Jacob Holland in Italian in the animated Netflix show "Il Mostro Dei Mari".
In 2023, he acted in the drama "Educazione Fisica" directed by Stefano Cipani, and returned in the second season of the series "Christian" as Matteo. He also voiced Super Mario in the animated movie "Super Mario Bros - The Movie".